In set-up
Open to recruitment
Closed to recruitment
Development of a patient reported outcome measure (PROM) for patients with inherited optic neuropathy (ION) [ION-PROM .
Study Team: Benson Chen, Patrick Yu Wai Man
Collaborators: Stephanie Archer (Cambridge), Valerija Tadić (Greenwich), Mike Horton (Leeds), Tasanee Braithwaite (Kings), Konrad Pesudovs (Sydney), Robert Pitceathley (UCL)
A phase IIa, randomised, double-blind, placebo-controlled trial of the ability of the combination of metformin and clemastine to promote remyelination in people with relapsing-remitting multiple sclerosis already on disease modifying therapy. Study Team: Nick Cunniffe, Chris McMurran, Will Brown, Alasdair Coles
The aim of the IIH Intervention study is to compare dural venous sinus stenting (DVSS) with cerebrospinal fluid (CSF) shunting in terms of effectiveness to prevent sight loss.
• Study Team: Collaboration between the Neurosurgeon, Dr Alexis Joannides and the University of Birmingham team.
An observation study Assessing Remyelinating Measures with the Objective of Understanding Repair in multiple sclerosis and in demyelinating conditions of the central nervous system.
Study Team: Gioia Riboni Verri, Jonathon Holland, Alasdair Coles, Nick Cunniffe, Riddhima Gautam
An observational Outcomes Research study in Inherited Optic Neuropathies to determine the natural history of inherited optic neuropathies and identify novel biomarkers of disease.
• Study Team: Benson Chen, Xuehao Cui, Rahul Makam, Patrick Yu Wai Man, Riddhima Gautam
Assessing Huntington’s Disease patients for ophthalmological abnormalities as a measure of disease stage.
• Study Team: Dimitrios Apostolopoulos, Roger Barker
An Open-label Study to Investigate the Safety, Tolerability, and Exposure of Single Ascending Doses of the Antisense Oligonucleotide STK-002 in Patients with Autosomal Dominant Optic Atrophy.
• Study Team: Patrick Yu Wai Man, Riddhima Gautam, Rahul Makam, David Wong
Previous studies
- Alzheimer Biomarker Consortium – Down Syndrome (ABC-DS) Study: Observational study to identify biomarkers of Alzheimer’s disease in people with Down’s syndrome.
- SPRINGER: Studying progressive remyelination in nerves by grading electrophysiological recovery
- Study Team: Nick Cunniffe, Chris McMurran, Trisha Mukherjee, Will Brown, Alasdair Coles
- PROSPAX: Understanding the progression over time of hereditary spastic paraplegia (HSP), ataxia and related conditions.
- Study Team: Benson Chen, Patrick Yu Wai Man